Antimalarial and cytotoxic activities of ethnopharmacologically selected medicinal plants from South Vietnam.
Identifieur interne : 000315 ( France/Analysis ); précédent : 000314; suivant : 000316Antimalarial and cytotoxic activities of ethnopharmacologically selected medicinal plants from South Vietnam.
Auteurs : Julie Nguyen-Pouplin [France] ; Hop Tran ; Hung Tran ; Tuyet Anh Phan ; Christiane Dolecek ; Jeremy Farrar ; Tinh Hien Tran ; Philippe Caron ; Bernard Bodo ; Philippe GrellierSource :
- Journal of ethnopharmacology [ 0378-8741 ] ; 2007.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : Antimalarials, Plant Extracts.
- geographic : Vietnam.
- chemistry : Plants, Medicinal.
- drug effects : Cell Proliferation, Plasmodium falciparum.
- Animals, Chloroquine, Drug Resistance, Ethnopharmacology, HeLa Cells, Humans.
Abstract
Malaria is a major global public health problem and the alarming spread of drug resistance and limited number of effective drugs now available underline how important it is to discover new antimalarial compounds. An ethnopharmacological investigation was undertaken of medicinal plants traditionally used to treat malaria in the South Vietnam. Forty-nine plants were identified, 228 extracts were prepared and tested for their in vitro activity against Plasmodium falciparum, and assessed for any cytotoxicity against the human cancer cell line HeLa and the embryonic lung MRC5 cell line. In a first screening at a concentration of 10 microg/ml, 92 extracts from 46 plants showed antiplasmodial activity (parasite growth inhibition >30%). The IC(50) values of the most active extracts were determined as well as their selectivity towards Plasmodium falciparum in comparison to their cytotoxic effects against the human cell lines. Six plants showed interesting antiplasmodial activity (IC(50) ranging from 0.4 to 8.6 microg/ml) with a good selectivity: two Menispermaceae, Arcangelisia flava (L.) Merr. and Fibraurea tinctoria Lour., and also Harrisonia perforata (Blanco) Merr. (Simaroubaceae), Irvingia malayana Oliv. ex Benn. (Irvingiaceae), Elaeocarpus kontumensis Gagn. (Elaeocarpaceae) and Anneslea fragrans Wall. (Theaceae).
DOI: 10.1016/j.jep.2006.08.011
PubMed: 17010546
Affiliations:
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pubmed:17010546Le document en format XML
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problem and the alarming spread of drug resistance and limited number of effective drugs now available underline how important it is to discover new antimalarial compounds. An ethnopharmacological investigation was undertaken of medicinal plants traditionally used to treat malaria in the South Vietnam. Forty-nine plants were identified, 228 extracts were prepared and tested for their in vitro activity against Plasmodium falciparum, and assessed for any cytotoxicity against the human cancer cell line HeLa and the embryonic lung MRC5 cell line. In a first screening at a concentration of 10 microg/ml, 92 extracts from 46 plants showed antiplasmodial activity (parasite growth inhibition >30%). The IC(50) values of the most active extracts were determined as well as their selectivity towards Plasmodium falciparum in comparison to their cytotoxic effects against the human cell lines. Six plants showed interesting antiplasmodial activity (IC(50) ranging from 0.4 to 8.6 microg/ml) with a good selectivity: two Menispermaceae, Arcangelisia flava (L.) Merr. and Fibraurea tinctoria Lour., and also Harrisonia perforata (Blanco) Merr. (Simaroubaceae), Irvingia malayana Oliv. ex Benn. (Irvingiaceae), Elaeocarpus kontumensis Gagn. (Elaeocarpaceae) and Anneslea fragrans Wall. (Theaceae).</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><noCountry><name sortKey="Bodo, Bernard" sort="Bodo, Bernard" uniqKey="Bodo B" first="Bernard" last="Bodo">Bernard Bodo</name><name sortKey="Caron, Philippe" sort="Caron, Philippe" uniqKey="Caron P" first="Philippe" last="Caron">Philippe Caron</name><name sortKey="Dolecek, Christiane" sort="Dolecek, Christiane" uniqKey="Dolecek C" first="Christiane" last="Dolecek">Christiane Dolecek</name><name sortKey="Farrar, Jeremy" sort="Farrar, Jeremy" uniqKey="Farrar J" first="Jeremy" last="Farrar">Jeremy Farrar</name><name sortKey="Grellier, Philippe" sort="Grellier, Philippe" uniqKey="Grellier P" first="Philippe" last="Grellier">Philippe Grellier</name><name sortKey="Phan, Tuyet Anh" sort="Phan, Tuyet Anh" uniqKey="Phan T" first="Tuyet Anh" last="Phan">Tuyet Anh Phan</name><name sortKey="Tran, Hop" sort="Tran, Hop" uniqKey="Tran H" first="Hop" last="Tran">Hop Tran</name><name sortKey="Tran, Hung" sort="Tran, Hung" uniqKey="Tran H" first="Hung" last="Tran">Hung Tran</name><name sortKey="Tran, Tinh Hien" sort="Tran, Tinh Hien" uniqKey="Tran T" first="Tinh Hien" last="Tran">Tinh Hien Tran</name></noCountry><country name="France"><region name="Île-de-France"><name sortKey="Nguyen Pouplin, Julie" sort="Nguyen Pouplin, Julie" uniqKey="Nguyen Pouplin J" first="Julie" last="Nguyen-Pouplin">Julie Nguyen-Pouplin</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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